福建农林大学植物保护学院
何玮毅
发布时间 :2021-03-04      浏览:8360

何玮毅,博士,教授,博士生导师


主要从事昆虫适应寄主植物的分子机制研究和基于基因组编辑的害虫遗传控制研究,围绕小菜蛾解毒寄主植物化学防御物质及其口腔效应蛋白调控寄主植物防御能力,借助基因组编辑技术,研究害虫适应寄主植物的分子策略及其遗传防控的新技术。

发表学术论文30余篇,主持国家自然科学基金、福建省自然科学基金等各类科研项目10项,获2018年度福建省自然科学奖一等奖1项(排名第3)。


工作经历

2023/06 – 至今,福建农林大学,植物保护学院,教授

2014/01 – 2023/05,福建农林大学,植物保护学院,副教授

2012/05 – 2013/12,福建农林大学,植物保护学院,讲师

2009/07 – 2012/05,福建农林大学,植物保护学院,博士后


授课内容

本科生:分子生物学导论,植物病虫害分子检测(实验)

研究生:昆虫分子生物学与基因组学

留学生:Professional Chinese for Plant Protection, Advanced Molecular Biology


研究方向

1. 小菜蛾适应寄主植物的分子机理

2. 害虫遗传控制


主持课题

 1. 国家自然科学基金面上项目(32472659),小菜蛾外泌体蛋白CD63协助效应蛋白GOX逃逸寄主植物防御反应的分子机制,2025/01-2028/12

 2. 福建省自然科学基金面上项目(2023J01069),外泌体介导小菜蛾适应寄主植物的功能和分子机理,2023/08-2026/08

 3. 国家自然科学基金面上项目(32172503),小菜蛾效应蛋白PxSROE经由生长素信号通路调控寄主甘蓝化学防御的分子机理,2022/01-2025/12

 4. 科技部国家重点研发计划课题任务(2017YFD0200400),活体生物农药增效及有害生物生态调控机制,2017/07-2021/03

 5. 福建省自然科学基金面上项目(2019J01369),肠道细菌介导小菜蛾适应寄主植物的效应及机理,2019/07-2022/06

 6. 国家自然科学基金青年项目(31301677),小菜蛾GSSSUMF1基因协同响应寄主植物硫苷及其分子基础,2014/01-2016/12

 7. 福建省自然科学基金面上项目(2014J01086),小菜蛾GSS基因响应寄主植物硫苷分子机制研究,2014/01-2016/12


参编专著

 1. 杨广、何玮毅、白建林、尤民生,第十一章 蔬菜害虫生态防控。尤民生主编,害虫生态防控的理论与实践。科学出版社,20231月。ISBN9787030723598

 2. Yue Wang, Minsheng You, Weiyi He*. 2021. Genome-wide identification and functional characterization of noncoding RNAs (ncRNAs) differentially expressed during insect development. In: Vaschetto L.M. (eds) RNAi Strategies for Pest Management. Methods in Molecular Biology, vol 2360, pp 1-8. Humana, New York, NY. ISBN: 978-1-0716-1633-8.


发表论文

 1. Yussuf Mohamed Salum, Anyuan Yin, Uroosa Zaheer, Yuanyuan Liu, Yi Guo*, Weiyi He*. CRISPR/Cas9-Based Genome Editing of Fall Armyworm (Spodoptera frugiperda): Progress and Prospects. Biomolecules, 2024, 14: 1074.

 2. Shanyu Li#, Guifang Lin#, Haoqi Wen, Haiyan Lu, Anyuan Yin, Chanqin Zheng, Feifei Li, Qingxuan Qiao, Lu Jiao, Ling Lin, Yi Yan, Xiujuan Xiang, Huang Liao, Huiting Feng, Yussuf Mohamed Salum, Minsheng You, Wei Chen*, Weiyi He*. Knock-in of exogenous sequences based on CRISPR/Cas9 targeting autosomal genes and sex chromosomes in the diamondback moth, Plutella xylostella. Journal of Integrative Agriculture, 2024, 23(9): 3089–3103.

 3. Uroosa Zaheer, Faisal Munir, Yussuf Mohamed Salum, Weiyi He*. Function and regulation of plant ARGONAUTE proteins in response to environmental challenges: a review. PeerJ, 2024, 12: e17115.

 4. Feiying Yang, Xiaodong Jing, Renfu Dong, Li Zhou, Xuejiao Xu, Yuhong Dong, Lingling Zhang, Ling Zheng, Yingfang Lai, Yusong Chen, Lianyun Lin, Xiaoli Ma, Minsheng You, Wei Chen*, Weiyi He*. Glucose oxidase of a crucifer-specialized insect: a potential role in suppressing plant defense via modulating antagonistic plant hormones. Journal of Agricultural and Food Chemistry, 2023, 71(45): 17469–17483.

 5. Wei Chen#*, Muhammad Bilal Amir#, Yuan Liao, Haizhong Yu, Weiyi He*, Zhanjun Lu*. New insights into the Plutella xylostella detoxifying enzymes: sequence evolution, structural similarity, functional diversity, and application prospects of glucosinolate sulfatases. Journal of Agricultural and Food Chemistry, 2023, 71(29): 10952–10969.

 6. Wei Chen, Yuhong Dong, Ling Zheng, Yingfang Lai, Feifei Li, Li Zhou, Beibei Wang, Minsheng You*, Weiyi He*. An inducible gene from glycoside hydrolase one family of Plutella xylostella decreases larval survival when feeding on host plant. Frontiers in Physiology, 2022, 13: 1013092.

 7. Bei-Bei Wang, Ying-Fang Lai, Fei-Fei Li, Lu Jiao, Qing-Xuan Qiao, Shan-Yu Li, Xiu-Juan Xiang, Huang Liao, Min-Sheng You*, Wei-Yi He*. Functional characterization of two RNA methyltransferase genes METTL3 and METTL14 uncovers the roles of m6A in mediating adaptation of Plutella xylostella to host plants. International Journal of Molecular Sciences, 2022, 23(17): 10013.

 8. Wei Chen#, Hafiz Sohaib Ahmed Saqib#, Xuejiao Xu#, Yuhong Dong, Ling Zheng, Yingfang Lai, Xiaodong Jing, Zhanjun Lu, Linyang Sun, Minsheng You*, and Weiyi He*. Glucosinolate sulfatases–sulfatase-modifying factors system enables a crucifer-specialized moth to pre-detoxify defensive glucosinolate of the host plant. Journal of Agricultural and Food Chemistry, 2022, 70(36): 10941-11440.

 9. Uttam Kumar#, Hafiz S.A. Saqib#*, Waqar Islam, Parmar Prashant, Nidhibahen Patel, Wei Chen, Feiying Yang, Minsheng You, Weiyi He*. Landscape composition and soil physical–chemical properties drive the assemblages of bacteria and fungi in conventional vegetable fields. Microorganisms, 2022, 10(6): 1202.

 10. Fei-Ying Yang, Jun-Hui Chen, Qian-Qian Ruan, Bei-Bei Wang, Lu Jiao, Qing-Xuan Qiao, Wei-Yi He*, Min-Sheng You*. Fitness comparison of Plutella xylostella on original and marginal hosts using age-stage, two-sex life tables. Ecology and Evolution, 2021, 11(14): 9765-9775.

 11. Fei-Ying Yang, Hafiz Sohaib Ahmed Saqib, Jun-Hui Chen, Qian-Qian Ruan, Liette Vasseur, Wei-Yi He*, Min-Sheng You*. Differential profiles of gut microbiota and metabolites associated with host shift of Plutella xylostella. International Journal of Molecular Sciences, 2020, 21(17): 6283.

 12. Minsheng You#*, Fushi Ke#, Shijun You#, Zhangyan Wu#, Qingfeng Liu#, Weiyi He#, Simon W. Baxter, Zhiguang Yuchi, Liette Vasseur*, Geoff M. Gurr*, Christopher M. Ward, Hugo Cerda, Guang Yang, Lu Peng, Yuanchun Jin, Miao Xie, Lijun Cai, Carl J. Douglas, Murray B. Isman, Mark S. Goettel, Qisheng Song, Qinghai Fan, Gefu Wang-Pruski, David C. Lees, Zhen Yue*, Jianlin Bai, Tiansheng Liu, Lianyun Lin, Yunkai Zheng, Zhaohua Zeng, Sheng Lin, Yue Wang, Qian Zhao, Xiaofeng Xia, Wenbin Chen, Lilin Chen, Mingmin Zou, Jinying Liao, Qiang Gao, Xiaodong Fang, Ye Yin, Huanming Yang, Jian Wang, Liwei Han, Yingjun Lin, Yanping Lu, Mousheng Zhuang. Variation among 532 genomes unveils the origin and evolutionary history of a global insect herbivore. Nature Communications, 2020, 11: 2321.

 13. Wei Chen, Yuhong Dong, Hafiz Sohaib Ahmed Saqib, Liette Vasseur, Wenwu Zhou, Ling Zheng, Yingfang Lai, Xiaoli Ma, Lianyun Lin, Xuejiao Xu, Jianlin Bai, Weiyi He*, Minsheng You*. Functions of duplicated glucosinolate sulfatases in the development and host adaptation of Plutella xylostella. Insect Biochemistry and Molecular Biology, 2020, 119: 103316.

 14. Ling-ling Zhang, Xiao-dong Jing, Wei Chen, Yue Wang, Jun-han Lin, Ling Zheng, Yu-hong Dong, Li Zhou, Fei-fei Li, Fei-ying Yang, Lu Peng, Liette Vasseur, Wei-yi He*, Min-sheng You*. Host plant-derived miRNAs potentially modulate the development of a cosmopolitan insect pest, Plutella xylostella. Biomolecules, 2019, 9(10): 602.

 15. Wei Chen, Feiying Yang, Xuejiao Xu, Uttam Kumar, Weiyi He*, Minsheng You*. Genetic control of Plutella xylostella in omics era. Archives of Insect Biochemistry and Physiology, 2019, 102(3): e21621.

 16. Wei Chen, Yuhong Dong, Lianyun Lin, Hafiz Sohaib Ahmed Saqib, Xiaoli Ma, Xuejiao Xu, Lingling Zhang, Xiaodong Jing, Lu Peng, Yue Wang, Liette Vasseur, Weiyi He*, Minsheng You*. Implication for DNA methylation involved in the host transfer of diamondback moth, Plutella xylostella (L.). Archives of Insect Biochemistry and Physiology, 2019, 102(2): e21600.

 17. Xiao-Li Ma#, Wei-Yi He#, Wei Chen, Xue-Jiao Xu, Wei-Ping Qi, Ming-Min Zou, Yan-Chun You, Simon W. Baxter, Ping Wang, Min-Sheng You*. Structure and expression of sulfatase and sulfatase modifying factor genes in the diamondback moth, Plutella xylostella. Insect Science, 2018, 25(6): 946-958.

 18. Weiping Qi#, Xiaoli Ma#, Weiyi He#, Wei Chen, Mingmin Zou, Geoff M. Gurr, Liette Vasseur, Minsheng You*. Characterization and expression profiling of ATP-binding cassette transporter genes in the diamondback moth, Plutella xylostella (L.). BMC Genomics, 2016, 17: 760.

 19. Weiqi Tang#, Liying Yu#, Weiyi He#, Guang Yang, Fushi Ke, Simon W. Baxter, Shijun You, Carl J. Douglas, Minsheng You*. DBM-DB: the diamondback moth genome database. Database, 2014, 2014: bat087.

 20. Minsheng You#*, Zhen Yue#, Weiyi He#, Xinhua Yang#*, Guang Yang#, Miao Xie#, Dongliang Zhan, Simon W. Baxter, Liette Vasseur, Geoff M. Gurr, Carl J. Douglas, Jianlin Bai, Ping Wang, Kai Cui, Shiguo Huang, Xianchun Li, Qing Zhou, Zhangyan Wu, Qilin Chen, Chunhui Liu, Bo Wang, Xiaojing Li, Xiufeng Xu, Changxin Lu, Min Hu, John W. Davey, Sandy M. Smith, Mingshun Chen, Xiaofeng Xia, Weiqi Tang, Fushi Ke, Dandan Zheng, Yulan Hu, Fengqin Song, Yanchun You, Xiaoli Ma, Lu Peng, Yunkai Zheng, Yong Liang, Yaqiong Chen, Liying Yu, Younan Zhang, Yuanyuan Liu, Guoqing Li, Lin Fang, Jingxiang Li, Xin Zhou, Yadan Luo, Caiyun Gou, Junyi Wang, Jian Wang, Huanming Yang, Jun Wang*. A heterozygous moth genome provides insights into herbivory and detoxification. Nature Genetics, 2013, 45(2): 220-225.

 21. Weiyi He, Minsheng You, Liette Vasseur, Guang Yang, Miao Xie, Kai Cui, Jianlin Bai, Chunhui Liu, Xiaojing Li, Xiufeng Xu, Shiguo Huang. Developmental and insecticide-resistant insights from the de novo assembled transcriptome of the diamondback moth, Plutella xylostella. Genomics, 2012, 99(3): 169–177.

 22. 李飞飞,王贝贝,赖颖芳,杨菲颖,尤民生*何玮毅*. fl(2)d单等位基因的敲除显著降低小菜蛾的生殖力和育性. 中国农业科学2021, 54(14): 3029-3042.

 23. 徐雪娇, 何玮毅, 杨婕, 陈玮, 尤民生*.害虫遗传防控技术的研究与应用. 中国科学: 生命科学, 2019, 49(8): 938-950.

 24. 董玉红, 陈玮, 郑玲, 荆晓东, 周立, 张玲玲, 李晓桐, 何玮毅*. 小菜蛾饲料品系转食寄主植物的适合度及其硫苷代谢相关基因表达. 福建农业学报, 2018, 33(1): 54-60.

 25. 陈玮, 徐雪娇, 陈楠菁, 何玮毅*, 尤民生*. 昆虫DNA甲基化的研究进展. 应用昆虫学报, 2015, 52(5): 1082-1093.

 26. 董人富, 马小丽, 陈亚琼, 戚伟平, 陈玮, 何玮毅*, 尤民生*. 昆虫葡萄糖氧化酶的基本特性及功能. 环境昆虫学报, 2015, 37(2): 426-431.


获批专利:

 1. 何玮毅,詹东亮,尤民生. 一种转录组数据的表达定量方法及系统. 福建农林大学,ZL 2018 1 0551976.62021-09-24.

 2. 陈玮,董玉红,何玮毅,荆晓东,张玲玲,尤民生. 昆虫-植物互作生物学观测简易装置. 福建农林大学,ZL 2019 2 0944680.02020-06-05.


获奖情况

 1. 尤民生,杨广,何玮毅,谢苗,岳震. 2018年度福建省自然科学奖一等奖,小菜蛾基因组的研究. 证书编号:2018-Z-1-004-03.

 2. 何玮毅. 第十一届福建省自然科学论文奖一等奖,小菜蛾转录组揭示其发育和抗药性机制,2014.08.


联系方式

福建农林大学 应用生态研究所

Email: wy_he[at]126.com; wy.he[at]foxmail.com